This newsletter is designed to share the exciting work of teachers and students participating in ITEST (Information Technology Experiences for Students and Teachers) projects across the United States. Participating educators and young people work hand in hand with scientists and engineers on extended research projects that carry them beyond the classroom, using technology to explore topics ranging from biotechnology to environmental resource management. In this issue, we spotlight the work of five ITEST projects, highlight upcoming presentations and publications, and link to valuable resources in the field.